Cholecalciferol

From Wikipedia: Cholecalciferol, also known as vitamin D3 and colecalciferol, is a type of vitamin D that is made by the skin when exposed to sunlight; it is found in some foods and can be taken as a dietary supplement.Cholecalciferol is made in the skin following UVB light exposure. It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25-dihydroxyvitamin D). One of its actions is to increase calcium uptake by the intestines. It is found in food such as some fish, beef liver, eggs, and cheese. Plants, cow milk, fruit juice, yogurt, and margarine also may have cholecalciferol added to them in some countries, including the United States.Cholecalciferol can be taken as an oral dietary supplement to prevent vitamin D deficiency or as a medication to treat associated diseases, including rickets. It is also used for familial hypophosphatemia, hypoparathyroidism that is causing low blood calcium, and Fanconi syndrome. Vitamin-D supplements may not be effective in people with severe kidney disease. Excessive doses in humans can result in vomiting, constipation, weakness, and confusion. Other risks include kidney stones. Doses greater than 40,000 IU (1,000 μg) per day are generally required before high blood calcium occurs. Normal doses, 800–2000 IU per day, are safe in pregnancy.Cholecalciferol was first described in 1936. It is on the World Health Organization's List of Essential Medicines. In 2020, it was the 60th most commonly prescribed medication in the United States, with more than 11 million prescriptions. Cholecalciferol is available as a generic medication and over the counter.

Coalition status

BCI Phase out by 2024 BCI Phase out by 2024

The Producer has a plan to phase out by 2024 pesticides listed in category 2 of the Globally Harmonized System of Classification and Labelling of…

FSC restricted HHPs FSC restricted HHPs
Chemical pesticide presenting one out of three of the following hazards: acute toxicity, chronic toxicity and environmental toxicity.

Details

Type: Pesticide
Use: Rodenticide
Example applications: -
Example pests controlled: Rats;Mice;Other rodents
Mode of action: Induces abnormally high levels of calcium in the blood
Source: PPDB

Toxicty

Fatal if inhaled (H330)
Fatal if inhaled
Mammal toxicity
Acute oral LD50 for most sensitive mammal species (LD50 < 200mg/kg bw).

Identifiers

Cas-RN: 67-97-0
Chebi: 10008
CiPac: 8063
EC: 200-673-2
PubChem: 5280795
US EPA: 202901

GHS safety labels

About Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
From Wikipedia: The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) is an internationally agreed-upon standard managed by the United Nations that was set up to replace the assortment of hazardous material classification and labelling schemes previously used around the world. Core elements of the GHS include standardized hazard testing criteria, universal warning pictograms, and harmonized safety data sheets which provide users of dangerous goods with a host of information. The system acts as a complement to the UN Numbered system of regulated hazardous material transport. Implementation is managed through the UN Secretariat. Although adoption has taken time, as of 2017, the system has been enacted to significant extents in most major countries of the world.[1] This includes the European Union, which has implemented the United Nations' GHS into EU law as the CLP Regulation, and United States Occupational Safety and Health Administration standards.
  • GHS06: Toxic
    H300

    Fatal if swallowed


    Class: Acute Toxicity
    Subclass: Oral
  • GHS06: Toxic
    H310

    Fatal in contact with skin


    Class: Acute Toxicity
    Subclass: Dermal
  • GHS06: Toxic
    H330

    Fatal if inhaled


    Class: Acute Toxicity
    Subclass: Inhalation
  • GHS08: Health hazard
    H372

    Causes damage to organs (state all organs affected, if known) through prolonged or repeated exposure (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard)


    Class: STOT
    Subclass: Repeated exposure

Cholecalciferol

Search on compound, trade name or registration number (CAS, Beilstein, Chebi)
From Wikipedia: Cholecalciferol, also known as vitamin D3 and colecalciferol, is a type of vitamin D that is made by the skin when exposed to sunlight; it is found in some foods and can be taken as a dietary supplement.Cholecalciferol is made in the skin following UVB light exposure. It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25-dihydroxyvitamin D). One of its actions is to increase calcium uptake by the intestines. It is found in food such as some fish, beef liver, eggs, and cheese. Plants, cow milk, fruit juice, yogurt, and margarine also may have cholecalciferol added to them in some countries, including the United States.Cholecalciferol can be taken as an oral dietary supplement to prevent vitamin D deficiency or as a medication to treat associated diseases, including rickets. It is also used for familial hypophosphatemia, hypoparathyroidism that is causing low blood calcium, and Fanconi syndrome. Vitamin-D supplements may not be effective in people with severe kidney disease. Excessive doses in humans can result in vomiting, constipation, weakness, and confusion. Other risks include kidney stones. Doses greater than 40,000 IU (1,000 μg) per day are generally required before high blood calcium occurs. Normal doses, 800–2000 IU per day, are safe in pregnancy.Cholecalciferol was first described in 1936. It is on the World Health Organization's List of Essential Medicines. In 2020, it was the 60th most commonly prescribed medication in the United States, with more than 11 million prescriptions. Cholecalciferol is available as a generic medication and over the counter.

Coalition status

BCI Phase out by 2024 BCI Phase out by 2024

The Producer has a plan to phase out by 2024 pesticides listed in category 2 of the Globally Harmonized System of Classification and Labelling of…

FSC restricted HHPs FSC restricted HHPs
Chemical pesticide presenting one out of three of the following hazards: acute toxicity, chronic toxicity and environmental toxicity.

Details

Type: Pesticide
Use: Rodenticide
Example applications: -
Example pests controlled: Rats;Mice;Other rodents
Mode of action: Induces abnormally high levels of calcium in the blood
Source: PPDB

Toxicty

Fatal if inhaled (H330)
Fatal if inhaled
Mammal toxicity
Acute oral LD50 for most sensitive mammal species (LD50 < 200mg/kg bw).

Identifiers

Cas-RN: 67-97-0
Chebi: 10008
CiPac: 8063
EC: 200-673-2
PubChem: 5280795
US EPA: 202901

GHS safety labels

About Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
From Wikipedia: The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) is an internationally agreed-upon standard managed by the United Nations that was set up to replace the assortment of hazardous material classification and labelling schemes previously used around the world. Core elements of the GHS include standardized hazard testing criteria, universal warning pictograms, and harmonized safety data sheets which provide users of dangerous goods with a host of information. The system acts as a complement to the UN Numbered system of regulated hazardous material transport. Implementation is managed through the UN Secretariat. Although adoption has taken time, as of 2017, the system has been enacted to significant extents in most major countries of the world.[1] This includes the European Union, which has implemented the United Nations' GHS into EU law as the CLP Regulation, and United States Occupational Safety and Health Administration standards.
  • GHS06: Toxic
    H300

    Fatal if swallowed


    Class: Acute Toxicity
    Subclass: Oral
  • GHS06: Toxic
    H310

    Fatal in contact with skin


    Class: Acute Toxicity
    Subclass: Dermal
  • GHS06: Toxic
    H330

    Fatal if inhaled


    Class: Acute Toxicity
    Subclass: Inhalation
  • GHS08: Health hazard
    H372

    Causes damage to organs (state all organs affected, if known) through prolonged or repeated exposure (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard)


    Class: STOT
    Subclass: Repeated exposure

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