From Wikipedia: 4-Aminopyridine (4-AP, fampridine, dalfampridine) is an organic compound with the chemical formula C5H4N–NH2. The molecule is one of the three isomeric amines of pyridine. It is used as a research tool in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. It was undergoing Phase III clinical trials as of 2008, and the U.S. Food and Drug Administration (FDA) approved the compound on January 22, 2010. Fampridine is also marketed as Ampyra (pronounced "am-PEER-ah," according to the maker's website) in the United States by Acorda Therapeutics and as Fampyra in the European Union, Canada, and Australia. In Canada, the medication has been approved for use by Health Canada since February 10, 2012.
Coalition status
FSC restricted HHPsChemical pesticide presenting one out of three of the following hazards: acute toxicity, chronic toxicity and environmental toxicity.
Details
Type: Pesticide
Use: Avicide, Acaricide, Repellent
Example applications: Public buildings;Agricultural fields
Example pests controlled: Red-winged blackbirds;Pigeons;Sparrows
Mode of action: Works as a potassium channel blocker, over stimulating the nervous system
Source: PPDB
Toxicty
Bird toxicity
Highly toxic to birds acute oral LD50 (LD50 < 200mg/bg bw)
Highly toxic to birds acute oral LD50 (LD50 < 200mg/bg bw)
Mammal toxicity
Acute oral LD50 for most sensitive mammal species (LD50 < 200mg/kg bw).
GHS safety labels
About Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
From Wikipedia: The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) is an internationally agreed-upon standard managed by the United Nations that was set up to replace the assortment of hazardous material classification and labelling schemes previously used around the world. Core elements of the GHS include standardized hazard testing criteria, universal warning pictograms, and harmonized safety data sheets which provide users of dangerous goods with a host of information. The system acts as a complement to the UN Numbered system of regulated hazardous material transport. Implementation is managed through the UN Secretariat. Although adoption has taken time, as of 2017, the system has been enacted to significant extents in most major countries of the world.[1] This includes the European Union, which has implemented the United Nations' GHS into EU law as the CLP Regulation, and United States Occupational Safety and Health Administration standards.
- H300
Fatal if swallowed
Class: Acute Toxicity
Subclass: Oral - H311
Toxic in contact with skin
Class: Acute Toxicity
Subclass: Dermal - H315
Causes skin irritation
Class: Corrosion/irritation
Subclass: Skin - H319
Causes serious eye irritation
Class: (Corrosion)Damage/irritation
Subclass: Eye - H335
May cause respiratory irritation
Class: STOT-respiratory irritation
Subclass: Single exposure - H411
Toxic to aquatic life with long lasting effects
Class: Aquatic
Subclass: Chronic